CCTST Grand Rounds
ABOUT GRAND ROUNDS
Grand Rounds is a monthly seminar series showcasing best practices in clinical and translational research and highlights exciting research in the field. The meeting is generally held the third Friday of every month via Zoom at noon and lasts for one hour. Recordings of past CCTST Grand Rounds presentations can be found on CTRonline under the CCTST Grand Rounds category.
For ideas or questions, please contact Katherine Bowers.
We proudly promote Medical Student Grand Rounds (MSGR), a lecture series delivered by UC College of Medicine medical students. For the latest information, please check out their website here.​
UPCOMING GRAND ROUNDS PRESENTATIONS
February 2025 Grand Rounds: Stewards of Science: Quantitative Partners Driving Ethical Translational Science
Friday, February 14, 2025 | 12:00pm - 1:00pm | Virtual via Zoom (Zoom link information can be found below)
Presentation Summary: Statisticians, data scientists, and informaticians are often valued for their technical skills, but underutilized as partners who can collaboratively shape research and policy. This talk introduces two key constructs—stewardship and translational science—to empower these professionals to redefine their roles. Embracing stewardship can enhance the ethical practice of (bio)statistics, data science, and informatics, while a formal and stewardly approach to translational science provides a framework for these quantitative research partners to actively shape research directions and outcomes. We will explore how stewardship can serve as a guiding principle for ethical practice, while translational science offers pathways for becoming, and being recognized as, active collaborators in multidisciplinary teams.
Professor
Department of Neurology
Georgetown University
Zoom Meeting Information:​
https://us06web.zoom.us/j/89145582857?pwd=7zwL3jOrHfGjsgbqGSMalwabTqtaO5.1
Meeting ID: 891 4558 2857
Passcode: 368771
March 2025 Grand Rounds: K Scholars Program Awardees Research Highlights
Friday, March 21, 2025 | 12:00pm - 1:00pm | Virtual via Zoom (Zoom link information can be found below)
We invite you to join us for a set of talks by rising stars at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine. The presenting junior faculty are all current awardees in the CCTST K Scholars Program conducting research to improve a range of health outcomes in children and adults.
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Chidiogo Anyigbo, MD, MPH
Assistant Professor
Division of General & Community Pediatrics, CCHMC
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Presentation Title: Socio-Contextual Influences of Infant and Early Childhood Mental Health
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Dr. Anyigbo’s research project aims to use electronic health record (EHR) data from pediatric primary care settings to identify early neighborhood and household social risk predictors of infant and early childhood behavioral functioning based on screenings completed by caregivers at routine well-child checks. The preliminary data will guide the design and feasibility testing of equitable household and neighborhood-based interventions to improve infant and early childhood behavioral health outcomes.
Nihal El Rouby, PharmD, PhD
Assistant Professor
College of Pharmacy, UC
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Presentation Title: Unlocking the risk of Metabolic Syndrome (MetS) post antipsychotics in pediatrics
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Dr. El Rouby’s research project utilizes the rich and diverse electronic health records such as the electronics medical records and genomics network (eMERGE) to define the prevalence of second-generation antipsychotics-induced Metabolic Syndrome (SGA-MetS) in pediatric and youth populations. Additionally she will investigate the ability of polygenic risk scores (PRS) to predict SGA-MetS. The long-term aim of this project is to integrate clinical and polygenic risk scores in the clinic to identify high-risk patients at the outset of treatment, enabling early interventions.
Shinsmon Jose, PhD
Research Assistant Professor
Department of Internal Medicine, UC
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Presentation Title: Targeted drug delivery to limit luminal neutrophils in Clostridioides difficile infection (CDI)
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Dr. Jose’s research project focuses on Clostridioides difficile infection (CDI). CDI is the leading cause of nosocomial infections in the U.S. It is classified as one of the top five organisms deemed to be an “urgent” public-health threat by the Centers for Disease Control and Prevention (CDC). The current treatment for acute CDI is to target the bacterium using antibiotics, often leaving the host inflammatory component of the disease unaddressed. While the initial driver of illness is C. difficile toxins, the host immune response contributes to the aggravation of the condition. In fact, the intensity of these host inflammatory responses is a better predictor of CDI outcomes than the pathogen burden. Thus, there is an urgent need to develop therapies to manage CDI-associated inflammation. Blood and tissue neutrophilia is a characteristic feature of the acute inflammatory response to CDI. Using a mouse model of CDI, Dr. Jose’s lab has identified that exaggerated host neutrophilia is a crucial driver of CDI-associated epithelial injury and disease severity. Dr. Jose and his team have also demonstrated that neutrophil mobilization to colonic tissue is driven by CXC chemokine receptor 2 (CXCR2). In this project, we propose developing a microencapsulated drug delivery system for the colonic delivery of CXCR2 inhibitors to prevent luminal recruitment of neutrophils and evaluate the delivered drug’s efficacy in reducing epithelial injury and disease severity. Findings from the study will improve the understanding of oral drug delivery to the colon during dysbiotic events and would provide the basis for independent funding to identify the potential of host-specific therapies in CDI.
Zoom Meeting Information:​
https://ucincinnati.zoom.us/j/88091253315?pwd=l4TfAfnsIB0gvA9RaEYmyiCweotrkY.1
Meeting ID: 880 9125 3315
Passcode: 2025